Seattle Seahawks at San Francisco 49ers betting tips and NFL predictions

Free American football tips, best bets and analysis for Seattle Seahawks at San Francisco 49ers in Week Two of the 2022 NFL season.

Where to watch

Sky Sports Main Event & NFL, 9.05pm Sunday

Best bet

San Francisco -9
2pts Evs bet365

Match preview

San Francisco 49ers were defeated in a scrappy game against the Bears in Week One, while Seattle Seahawks won an emotional encounter against the Broncos.

Though it’s important not to read too closely into either of those results, and understand that Sunday's Week Two contest is a perfect time to get with the 49ers.

San Francisco subsided against the Bears as quarterback Trey Lance struggled, but the terrible weather conditions must be taken into consideration and it's likely that the 49ers will bounce back when the Seahawks visit California.

Lance and the Niners get to take on a Seattle defence who will be playing after one less day of rest and without star safety Jamal Adams.

While Seahawks quarterback Geno Smith put in a tremendous performance against the Broncos last week, he will face a much tougher test against the 49ers and may struggle to get his offence moving.

Outside of top receiver DK Metcalf, Seattle do not have much in their favour on attack and rookie left tackle Charles Cross faces a tough task in containing 49ers pass-rusher Nick Bosa.

San Francisco are expected to be one of the top teams in the NFL this season and they can show their class here.

Take the 49ers to beat the Seahawks by double digits.

The lowdown

Venue Levi's Stadium
Surface Hybrid
Weather Light rain, 19C
Vegas handicap Seattle +9
Vegas points line 41

Key stat

The 49ers have covered the spread in four of their last five home games.

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