Solid Saints have got a prayer against Red Devils
The Red Devils won 4-0 at home to Everton last Sunday but the game was in the balance until they scored three goals in the last ten minutes.
Southampton have kept clean sheets in three of their five league matches this season and can hold their own.
1pt 14-5 bet365, 188Bet
Virgil van Dijk played for the Under-23 side in midweek and could be ready to start but Matt Targett (ankle) is a doubt.
Paul Pogba (hamstring), Marcos Rojo and Zlatan Ibrahimovic (both knee) remain sidelined but no fresh injuries have been reported since the 4-1 victory over Burton on Wednesday.
United have won one of their last six away league fixtures.
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