Saints look set to tame the Tigers
Hull may slip deeper into the mire with a home defeat to Southampton.
Saints played on Thursday but will feel confident after coming from behind to register a 2-1 success at home to Inter in the Europa League.
They also have fresh legs to come back into the side as Jose Fonte, Charlie Austin and Steven Davis were benched in midweek. Hull are on a six-match Premier League losing sequence.
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Hull Dieumerci Mbokani (hamstring) returns to the squad and Robert Snodgrass (ankle) could be involved but Andy Robertson, Allan McGregor and Moses Odubajo remain sidelined.
Southampton Shane Long, Cedric Soares, Matt Targett and Alex McCarthy remain in the Saints’ treatment room.
Hull have not kept a clean sheet in their last 11 matches