Real test for La Liga leaders Madrid
Two of this season's three meetings between Atletico Madrid and Barcelona have been draws and the points could be shared at the Vicente Calderon.
Barcelona have had the benefit of a free midweek but may struggle to get the better of Atletico, who were impressive 4-2 winners away to Bayer Leverkusen on Tuesday.
Dan Childs's recommendation
1pt 5-2 188Bet
Atletico have lost one of their last 28 La Liga home matches
A home banker a few weeks ago, Granada have picked up two wins in their last three games including an impressive 4-1 win against Betis. Granada are yet to win on the road but can profit from Athletic's Euro hangover by nicking a precious point.
Steve Davies's recommendation
1pt 7-2 general
Granada have failed to keep an away clean sheet in 12 months
Villarreal v Real Madrid Sky Sports 1, 7.45pm
Real Madrid will look to bounce back from the disappointment of losing in Valencia on Wednesday but this is a tricky trip against a Villarreal side who have tested all of La Liga's big clubs this term.
The Yellow Submarine, who picked up a point in the reverse fixture, have held Seville and Barcelona at home this season and beaten Atletico Madrid so they should play their part in a decent match.
Mark Langdon's recommendation
Both teams to score
1pt 13-18 188Bet
Both teams have scored in 13 of Real Madrid's last 14 away matches