Portuguese club can book place in knockout stages
BT Sport Extra, 7.45pm
Both will advance if third-placed Besiktas lose away to Dynamo Kiev but a Besiktas victory would ensure that one of them falls out of the top two.
Napoli need just a draw to see them through but have not won in their last three Champions League matches and have become less effective since key striker Arkadiusz Milik sustained a long-term knee injury during the October international break.
Losing an influential forward is not such an issue for teams who have a reliable defence but Napoli have not kept an away clean sheet since September.
Benfica have got better as the competition has progress ed, taking seven points from the last three games, and look value 8-5 shots to win again.
1pt 8-5 Betfair
Benfica Eliseu (thigh), Alex Grimaldo (stomach) and Jonas (foot) are sidelined.
Napoli Arkadiusz Milik (knee) is out long-term.
Napoli have not kept a clean sheet in their last five away matches