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Buffalo Bills at Houston Texans: NFL predictions, betting tips and odds

Buffalo Bills visit Houston Texans in Week 12 of the 2025 NFL season. Get match details, betting tips, predictions and TV info for Thursday's game

Buffalo Bills quarterback Josh Allen
Buffalo Bills quarterback Josh AllenCredit: Michael Reaves

Buffalo Bills at Houston Texans date, start time & TV info 

Date Thursday, November 20
Starts 1.15am GMT
Venue NRG Stadium, Houston, Texas
TV Sky Sports NFL

An interesting AFC match-up kicks off Week 12 in the NFL as the Buffalo Bills visit the Houston Texans on Thursday night. 

The Bills (7-3) are trailing the red-hot New England Patriots (9-2) in the AFC East while the Texans (5-5) are in third place in the AFC South.

Buffalo Bills at Houston Texans betting tips & predictions

Best bet

Under 43.5 points
1pt 19-20 Coral, Ladbrokes

Buffalo Bills at Houston Texans preview 

Buffalo bounced back to form last week with a thrilling 44-32 home win over Tampa Bay, but points may be harder to come by when they visit a solid Houston team in the opening contest of Week 12.

The 7-3 Bills had endured an awful 30-13 road defeat at the hands of Miami the previous week, but star quarterback Josh Allen passed for three touchdowns and ran in three more as the Bucs were put to the sword.

Houston have improved to reach 5-5 after a 0-3 start and have won their last two games, but they struggled to put the league's worst team, the 1-9 Tennessee Titans, to bed last week, winning a scrappy game 16-13.

The Texans' defence ranks first in the league for yards allowed at just 258.1 per game, and this could be another close and relatively low-scoring clash similar to Houston's 23-20 win in the teams' last meeting.

The hosts have conceded only 16.3 points per game on average this season but they are again set to be without first-choice quarterback CJ Stroud (concussion) and Davis Mills may not have much success against the Bills' defence.

Last season the Texans restricted Allen to just 131 passing yards. While he should do better this time, the total points line may prove to be a tad high.


Click here to get our exclusive 12-1 Bet Builder for Buffalo at Houston


Buffalo Bills at Houston Texans betting odds

Here are Paddy Power's latest odds for Thursday's game.

Match bettingOdds
Buffalo Bills4-11
Houston Texans11-5
Handicap
Buffalo Bills -5.517-20
Houston Texans +5.519-20
Total points
Under 43.510-11
Over 43.510-11

Odds correct at time of publishing


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FAQs for Buffalo Bills at Houston Texans

When is Buffalo Bills at Houston Texans in the NFL?

Buffalo Bills visit the Houston Texans in the opening game of Week 12 on Thursday, November 20. The game starts at 1.15am GMT Friday morning.

Where is Buffalo Bills at Houston Texans being played?

The game will take place at NRG Stadium in Houston, Texas, which has an artificial surface.

What are the odds for Buffalo Bills at Houston Texans?

The Bills are clear 4-11 favourites on the road with the Texans the 11-5 home underdogs. The handicap is set at 5.5 points.


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