Hammers can deal Wenger another blow
Laurent Koscielny – the Gunners' most reliable defender – was injured during Sunday's 2-2 draw with Manchester City and a reshaped Arsenal defence will have to cope with Michail Antonio, who returns to contention for West Ham.
A poor run for the Hammers has seen them drop to within six points of the relegation zone but a big London derby could be just the spark they need.
West Ham or draw double chance
1pt 21-10 BoyleSports
Aaron Ramsey (calf) and Alex Oxlade-Chamberlain (hamstring) face fitness tests but Laurent Koscielny (Achilles) is out and Petr Cech will not be available until Monday's clash at Crystal Palace.
Michail Antonio (hamstring) and Diafra Sakho (back) are in the squad but Aaron Cresswell is sidelined after picking up an injury in the 2-1 loss at Hull.
Arsenal have won one of their last six league games.